The correlation between 1H-MR spectroscopy and clinical manifestation with tuberous sclerosis complex

9Citations
Citations of this article
23Readers
Mendeley users who have this article in their library.

Abstract

Tuberous sclerosis complex (TSC) is an autosomal dominant neurocutaneous disease. Cortical tubers are one of the standard intracranial hallmarks of TSC, they comprise subependymal hamartomas protruding into the ventricles, cortical and white matter hamartomas, and giant cell tumors. The clinical course of TSC varies from asymptomatic to severe, with epileptic seizures and psychomotor retardation. We discuss here the correlation between clinical manifestation and features on 1H-MR spectroscopy (1H-MRS) of the white matter involving cortical tubers in patients with TSC. Statistical analysis of the N-acetylaspartate (NAA), choline (Cho) and myoinositol (ml)/creatinine (Cr) ratios between tubers and normal controls showed decreased NAA/Cr and increased ml/Cr ratios (P < 0.05) in tubers, but no significance difference in Cho/Cr. The significance of the clinical appearance is associated with a decreased ratio of NAA/Cr in tubers with TSC. An elevated ratio of ml/Cr in tuber does not parallel the severity of the clinical features of TSC. These findings suggest that 1H-MRS may be useful for the evaluation of the clinical severity and prognostic diagnosis of TSC. © Georg Thieme Verlag KG Stuttgart.

References Powered by Scopus

Medical progress: The tuberous sclerosis complex

1450Citations
N/AReaders
Get full text

Molecular genetic and phenotypic analysis reveals differences between TSC1 and TSC2 associated familial and sporadic tuberous sclerosis

221Citations
N/AReaders
Get full text

Cortical tuber count: A biomarker indicating neurologic severity of tuberous sclerosis complex

202Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Astrocytes in the initiation and progression of epilepsy

78Citations
N/AReaders
Get full text

Pulsed arterial spin-labeled MR imaging evaluation of tuberous sclerosis

25Citations
N/AReaders
Get full text

Significance of tuber size for complications of tuberous sclerosis complex

18Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Matsuo, N., Imamura, A., Ito, R., Sugawara, K., Takahashi, Y., & Kondo, N. (2007). The correlation between 1H-MR spectroscopy and clinical manifestation with tuberous sclerosis complex. Neuropediatrics, 38(3), 126–129. https://doi.org/10.1055/s-2007-985368

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 8

50%

Researcher 5

31%

Lecturer / Post doc 3

19%

Readers' Discipline

Tooltip

Medicine and Dentistry 8

57%

Neuroscience 4

29%

Engineering 1

7%

Psychology 1

7%

Save time finding and organizing research with Mendeley

Sign up for free