Oxidative stress and therapeutic development in lung cancer

Abstract

Oxidative stress is associated with the pathogenesis of many lung diseases including lung cancer. The main goal of this chapter is to provide an overview of how reactive oxygen species (ROS) and antioxidants are related to normal physiological function and the pathophysiology of lung cancer and its therapeutic strategies. In this chapter, ROS are first characterized, followed by the role of oxidative stress in progression of different lung cancers, and a brief overview of therapeutic strategies developed gradually over the decades for better therapy of lung cancer is described. Limitations of current strategies and failures of clinical trials have also been discussed, and finally development of new therapy which may be helpful in the treatment of patients with lung cancer has also been addressed as future direction.