Neurochemical and Neuroendocrine Considerations of Obsessive-Compulsive Disorders in Childhood

Abstract

presents relevant information from both patient groups, adults and children, in order to examine the neuropathology of OCD [Obsessive Compulsive Disorder] more fully several etiologic theories, currently under investigation in OCD, are reviewed in this chapter / these include serotonin dysfunction, as suggested by the selective efficacy of clomipramine, a tricyclic antidepressant (TCA) with particular efficacy in blocking serotonin reuptake, and by challenge tests / dysfunction of other neurotransmitters, including dopamine, is considered / the compelling evidence for the involvement of hormones, particularly the androgens, in the etiology of OCD is summarized / finally, a hypothetical model of basal ganglia dysfunction, which incorporates the most widely accepted of these theories, is presented and defended (PsycINFO Database Record (c) 2016 APA, all rights reserved)