New polyenic antibiotics active against gram-positive and gram-negative bacteria: IV. structural elucidation of enacyloxin ha

Abstract

The chemical structure of a unique polyenic antibiotic enacyloxin IIa (former name: fr. 2) produced by Frateuria (formerly Gluconobacter) sp. W-315 has been determined by extensive spectroscopic studies, in particular by NMR spectral analysis. It has a novel non-lactonic structure involving 3,4-dihydroxycyclohexanecarboxylic acid with a chlorine-containing polyenic and polyhydroxy acyl side chain attached as an ester to the 3-hydroxyI substituent of the acid. © 1992, JAPAN ANTIBIOTICS RESEARCH ASSOCIATION. All rights reserved.