Stereoselectivity of the hydrogenation of galactofuranosyl exoglycals

Abstract

This work describes a study of the α/β-diastereoselectivity of the hydrogenation of phosphonylated exoglycals in the galactofuranose series. Nine exoglycals displaying sterically hindering groups on the α or the β face have been synthesized and hydrogenated using Pearlman's catalyst. These reactions gave the expected C-glycoside with good to excellent α -selectivities. ©ARKAT-USA, Inc.