Antidiabetic Activity and Molecular Docking Analysis of Milky Mushroom (Calocybe indica) Grown on the Renewable Substrate

Abstract

As part of the circular economy idea, rice straw without additives has been investigated as a way to turn agricultural waste into products with added value. The nutrients in the substrate, Calocybe indica yield, and biological effects were all calculated. In this investigation, the methanol extract was used. GCMS was examined to discover the necessary compounds present in fungi. A surplus of mushrooms was harvested, and it was discovered that the growth of mushrooms on the rice substrate took place in less than five days. At a humidity of 93%, biological efficiency was determined to be in the range of 54.5-130.9%. In vitro and molecular docking results for the antidiabetic showed good inhibitory properties. As a result, rice straw could be a productive and affordable growing medium for milky mushrooms.