The effect of cancer chemotherapeutic agents on fibrin formation and stabilization in vitro

Abstract

Functional and morphologic studies of fibrin formation in the presence of a variety of cancer chemotherapeutic agents in vitro showed that some of these drugs cause fibrinolysis, inactivation of fibrin-stabilizing factor (FSF), or a combination of both. The drugs with most potent activity are 5-[3,3-bis(2-chloroethyl)-l-triazeno]imidazole-4- carboxamide (TIC mustard), 5-fluorouracil, nitrogen mustard, adriamycin, and daunomycin. These changes were dose related. © 1974 International Pediatric Research Foundation, Inc.