Accelerated metabolism of voriconazole and its partial reversal by cimetidine

Abstract

We report a case of accelerated metabolism of voriconazole during therapy for invasive pulmonary aspergillosis, resulting in subtherapeutic levels. Target voriconazole levels were restored with high dosages of voriconazole (up to 40 mg/kg of body weight/day) and the addition of Cimetidine as a cytochrome P450 enzyme inhibitor. Copyright © 2009, American Society for Microbiology. All Rights Reserved.