Androgens are critical for normal prostate development and function, as well as prostate cancer initiation and progression. Androgens function mainly by regulating target gene expression through the androgen receptor (AR). Many studies have shown that androgen-AR signaling exerts actions on key events during prostate carcinogenesis. In this review, androgen action in distinct aspects of prostate carcinogenesis, including (i) cell proliferation, (ii) cell apoptosis, and (iii) prostate cancer metastasis will be discussed.
CITATION STYLE
Wang, D., & Tindall, D. J. (2011). Androgen Action During Prostate Carcinogenesis. In Methods in Molecular Biology (Vol. 776, pp. 25–44). Humana Press Inc. https://doi.org/10.1007/978-1-61779-243-4_2
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