Sphingolipids in Neuroinflammation

Abstract

Sphingolipids, the main component of cellular membranes, are cellular 'jack-of-All-trades', influencing a variety of functions including signal transduction, cell activation, membrane fluidity and cell-cell interactions. In the last few years, sphingolipids have begun to be investigated in the pathophysiology of major diseases of the brain, e.g. multiple sclerosis and dementia. Modulation of neuroinflammatory responses, such as lymphocyte behaviour, is a chance to intervene in the pathways that cause disease. There is much research still to be done in this field, but the prospect of treating previously untreatable medical conditions compels us onwards. Here, we review the current knowledge of the link between sphingolipids and neuroinflammation. © Springer-Verlag Wien 2013.