Synthesis of novel 1,2-diphenylpyrrole derivatives using organophosphorus reagents and their antitumour activities

Abstract

The reactions are reported of 4-(furan-3-ylcarbonyl)-1,5- diphenylpyrrolidine-2,3-dione with six classes of organophosphorus reagents: carboalkoxymethylene triphenylphosphoranes, triphenyl (phenylimino)-λ5- phosphane, trialkylphosphonoacetates, trialkylphosphites, tris (dialkylamino)phosphines, and Lawesson's reagent. Several of the products showed antitumour activity. © 2014 Publishing Technology.