Effect of oscillatoria willei - a marine cyanobacterium on hydrazine induced toxicity

Abstract

Aims: To find out the effect of crude extract of Oscillatoria willei, a marine cyanobacterium on hydrazine induced toxicity. Methodology and Results: In this study, the experimental mice were injected intramuscularly with 5 mg of hydrazine/kg body weight continuously for 20 days. Crude extract of Oscillatoria willei was given to the animals induced with hydrazine toxicity. The animals were subjected to various biochemical and immunological parameters after exposing to hydrazine and followed up treatment. The results revealed that intra-peritoneal administration of O. willei reduced interleukin 2 (IL-2), reducing sugar, thiobarbituric acid reactive substances (TBARS), liver enzymes, bilirubin, creatinine and uric acid level. Conclusion, significance and impact of study: O. willei treatment was found to reduce the ill effects induced by hydrazine.