The intrinsic and extrinsic factors that contribute to stem and neuronal precursor cell maintenance and/or differentiation remain poorly understood. Proteoglycans, major residents of the stem cell microenvironment, modulate key signaling cues and are of particular importance. We have taken a loss-of-function approach, by developing a library of bacterial lyases and sulfatases to specifically remodel the ECM and test the functional role of glycosaminoglycans (GAGs) in cell self-renewal, maintenance, and differentiation.
CITATION STYLE
Cortes, M., Cortes, L. K., & Schwartz, N. B. (2015). Mapping proteoglycan functions with glycosidases. Methods in Molecular Biology, 1229, 443–455. https://doi.org/10.1007/978-1-4939-1714-3_34
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