Cutting Edge: Role of TANK-Binding Kinase 1 and Inducible IκB Kinase in IFN Responses against Viruses in Innate Immune Cells

  • Matsui K
  • Kumagai Y
  • Kato H
  • et al.
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Abstract

TANK-binding kinase 1 (TBK1) and inducible IκB kinase (IKK-i) are involved in the activation of transcription factors inducing the production of type I IFNs. Although TBK1, but not IKK-i, is critical for LPS-induced IFN induction, the role of these kinases in the responses against viral infection is yet to be determined. In this study, we show that type I IFN production against various RNA viruses was completely abrogated in conventional dendritic cells (DCs) and macrophages induced from fetal liver cells lacking both TBK1 and IKK-i, whereas considerable amounts of IFN were produced in cells lacking either of them. Microarray analysis revealed that various IFN-inducible genes were also regulated by the kinases. In contrast, Fms-like tyrosine kinase 3 ligand-induced DCs produced IFN-α even in the absence of both TBK1 and IKK-i. Thus, these two kinases are essential and compensate each other for the regulation of IFN responses in innate immune cells except plasmacytoid DCs.

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APA

Matsui, K., Kumagai, Y., Kato, H., Sato, S., Kawagoe, T., Uematsu, S., … Akira, S. (2006). Cutting Edge: Role of TANK-Binding Kinase 1 and Inducible IκB Kinase in IFN Responses against Viruses in Innate Immune Cells. The Journal of Immunology, 177(9), 5785–5789. https://doi.org/10.4049/jimmunol.177.9.5785

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