An inverse relationship between the concentration of high-density lipoprotein (HDL) cholesterol and the risk of developing cardiovascular is well established. There are several documented functions of HDLs that may contribute to a protective role of these lipoproteins. These include the ability of HDLs to promote the efflux of cholesterol from macrophages and foam cells in the artery wall and to anti-inflammatory/antioxidant properties of these lipoproteins. The fact that the main apolipoprotein of HDLs, apoA-I, plays a prominent role in each of these functions adds support to the view that apoA-I should be measured as a component of the assessment of cardiovascular risk in humans. © 2006 Blackwell Publishing Ltd.
CITATION STYLE
Barter, P. J., & Rye, K. A. (2006). The rationale for using apoA-I as a clinical marker of cardiovascular risk. In Journal of Internal Medicine (Vol. 259, pp. 447–454). https://doi.org/10.1111/j.1365-2796.2006.01647.x
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