Insulin resistance in PCOS

Abstract

Insulin resistance refers to the state, wherein insulin action is insufficient to accomplish the metabolic demands of peripheral tissues, despite the increased amounts of insulin secreted in the circulation. However, this is only an approximate description of this disorder. Insulin resistance encompasses an elaborate clinical, pathophysiologic, and molecular spectrum, and therefore, a well-established definition remains elusive. © 2009 Springer-Verlag US.