The problem of aggressive behavior in epilepsy: Clinical and neurobiological aspects

Abstract

Aggressive behavior is observed in a significant number of patients with epilepsy. The aggressive behavior is associated with structural and functional changes in the amygdala, orbitofrontal cortex and striatum. From the clinical point of view, aggressive behavior more often is not related to the seizure, and develops as part of borderline psychiatric disorder. Another potential cause of aggressive behavior is postictal psychotic disorder. Pre-and intraictal aggressive behavior is rarely observed. Anticonvulsants may influence differently on aggression. Antidepressants, neuroleptics, normotimics and psychotherapy are used in correction of aggression.