Years of meticulous curation of scientific literature and increasingly reliable computational predictions have resulted in creation of vast databases of protein interaction data. Over the years, these repositories have become a basic framework in which experiments are analyzed and new directions of research are explored. Here we present an overview of the most widely used protein-protein interaction databases and the methods they employ to gather, combine, and predict interactions. We also point out the trade-off between comprehensiveness and accuracy and the main pitfall scientists have to be aware before adopting protein interaction databases in any single-gene or genome-wide analysis.
CITATION STYLE
Szklarczyk, D., & Jensen, L. J. (2015). Protein-protein interaction databases. Methods in Molecular Biology, 1278, 39–56. https://doi.org/10.1007/978-1-4939-2425-7_3
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