The importance of interaction between hyaluronic acid and CD44 receptor

Abstract

Hyaluronic acid is one of the most used substances in dermatology. It presents structural rolesin the extracellular matrix, binding to cells and biological components through specific andnonspecific interactions. The native ligand for hyaluronic acid is the transmembrane CD44receptor, which interacts not only with hyaluronic acid but also with different growth factors,cytokines, and extracellular matrix proteins. We seek to review the interaction of the CD44receptor with the various forms of hyaluronic acid in the skin to better understand its actionand fully explore its use in dermatology