Structural glycobiology: How to gain insight into the structure-function relationship

Abstract

Glycosylation of proteins is a widespread feature in nature. Important is the question concerning the function of the carbohydrate chains of proteins in biological systems. The proposed funtions deal on the one hand with the physico-chemical properties, and on the other hand with direct or indirect involvement in biological processes. However, before any biological effect can be achieved, interaction with complementary molecules is a prerequisite. To gain insight into the interaction features it is essential to have a profound knowledge of the 3-dimensional structure of at least that part of the molecule that is involved. Various aspects of the structure are considered with respect to uniqueness.