Relationship between serum leptin levels and alcohol consumption in a controlled feeding and alcohol ingestion study

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Abstract

We examined serum leptin levels in a controlled feeding and alcohol ingestion study to elucidate potential mechanisms by which alcohol may affect cancer and immunologically related health risks. A total of 53 healthy, nonsmoking postmenopausal women completed a random-order, three-period crossover design study in which each woman received zero (0 g of alcohol), one (15 g of alcohol), or two (30 g alcohol) drinks per day. After accounting for differences in body mass index, women who consumed 15 or 30 g of alcohol per day had 7.3% (95% confidence interval [CI] = 3.0% to 15.1%) and 8.9% (95% CI = 1.6% to 16.7%) higher serum leptin levels, respectively (Ptrend = .018), than women who consumed 0 g of alcohol per day. Younger women (i.e., 49-54 years) demonstrated a statistically significantly larger association of alcohol consumption level with the increase in serum leptin levels than older women (i.e., 55-79 years) (24.4%, 95% CI = 9.3% to 42.0% versus 3.7%, 95 % CI = -4.1 % to 12.1 % increase in serum leptin levels for 30 g of alcohol per day relative to 0 g of alcohol per day for the lowest age quartile compared with the three highest age quartiles combined; P =.022). These results indicate that moderate alcohol consumption (15-30 g of alcohol per day) increases serum leptin levels in postmenopausal women and may predispose moderate drinkers to the morbidities associated with chronic elevations of this hormone including cancer.

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Roth, M. J., Baer, D. J., Albert, P. S., Castonguay, T. W., Dorgan, J. F., Dawsey, S. M., … Taylor, P. R. (2003). Relationship between serum leptin levels and alcohol consumption in a controlled feeding and alcohol ingestion study. Journal of the National Cancer Institute, 95(22), 1722–1725. https://doi.org/10.1093/jnci/djg090

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