Human Dentin as Novel Biomaterial for Bone Regeneration

Abstract

BMP-2 strongly accelerated bone formation in the DDM carrier system. DDM never inhibited BMP-2 activity and revealed better release profile of BMP-2. These results indicate that human recycled DDM are unique, absorbable matrix with osteoinductivity and the DDM should be an effective graft material as a carrier of BMP-2 delivering and a scaffold for bone-forming cells for bone engineering.