Sequence-specific targeting of double-stranded DNA (dsDNA) using synthetic oligonucleotides (ONs) has been under investigation in different therapeutic approaches. Several methods can be used to evaluate ONs effect and binding capacity to their target sequence. Here we describe some of the methods, which have been frequently used for assessing ONs binding to dsDNA.
CITATION STYLE
Mozafari, N., & Umek, T. (2019). Assessing Oligonucleotide Binding to Double-Stranded DNA. In Methods in Molecular Biology (Vol. 2036, pp. 91–112). Humana Press Inc. https://doi.org/10.1007/978-1-4939-9670-4_5
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