The Obesogen Hypothesis: Current Status and Implications for Human Health

Abstract

Obesity and diabetes have overtaken smoking as the number 1 preventable health determinate in the United States. In its basic form, obesity is due to disruptions of the endocrine systems that control food intake, satiety, and metabolic rate. Recent studies have identified a subclass of endocrine disrupting chemicals that interfere with hormonally regulated metabolic processes, especially during early development. These chemicals, called “obesogens,” may predispose individuals to gain weight despite efforts to limit caloric intake and increase physical activity. Evidence suggests that chemical exposures early in life can predispose individuals to weight gain through programming changes, which may enhance dysfunctional eating behaviors later in life. This review examines the latest research on the obesogen hypothesis and its underpinnings in the Developmental Origins of Heath and Disease model. We provide examples of known and suspected obesogens, and evidence of their general mechanisms of action. The research reviewed here provides a solid foundation of knowledge from which health scientists may draw from and build upon to inform their research and decision-making.