Neural Stem Cell Activation and the Role of Protein Synthesis

  • Baser A
  • Skabkin M
  • Martin-Villalba A
N/ACitations
Citations of this article
86Readers
Mendeley users who have this article in their library.

Abstract

Adult neural stem cells are generated at embryonic stages by entering a quiescent state that allows their retention into adulthood and thereby maintenance of lifelong brain homeostasis. Thus, a tight balance between the quiescence and activation state is instrumental to meet the brain demands for a specific cell type at the correct numbers, at a given time and position. Protein synthesis is the most energy-consuming process within the cell and, not surprisingly, it occurs at low rates in quiescent stem cells. This way quiescent cells adjust to energy constraints and avoid their premature depletion. Stem cell activation is characterized by upregulation of protein synthesis followed by cell division and differentiation. The role of such upregulation as causative or rather a consequence of the activation remains elusive. Here we summarize recent findings connecting stem cell activation to the regulation of protein synthesis, particularly focusing on embryonic and adult neural stem cells of the ventricular zone.

Cite

CITATION STYLE

APA

Baser, A., Skabkin, M., & Martin-Villalba, A. (2017). Neural Stem Cell Activation and the Role of Protein Synthesis. Brain Plasticity, 3(1), 27–41. https://doi.org/10.3233/bpl-160038

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Save time finding and organizing research with Mendeley

Sign up for free