Spontaneous regression in an ulcerated CK7 positive Merkel cell carcinoma

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Abstract

Merkel cell carcinoma is an aggressive and frequently lethal tumor of the elderly, Associated with sun exposure and immunosuppression which is less common in the dark-skinned. We report the case of a 40-year-old woman who presented with multiple slowly progressive, mildly itchy ulcerated plaques of size ranging from 2 × 3 cm to 5 × 7 cm on the left knee of 1 year duration. Skin biopsy showed diffuse dermal infiltration by small round cells with molding of cells and lymphocyte infiltration. The cells stained positive for cytokeratin (CK) 20, CK7, neuron-specific enolase, and chromogranin. The skin lesions underwent spontaneous regression within 1 month of skin biopsy and have not recurred during the past 2 years. The immune mechanisms triggered by biopsy possibly explain the spontaneous regression.

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Khader, A., George, S., Balakrishnan, S., & Aravindan, K. P. (2015). Spontaneous regression in an ulcerated CK7 positive Merkel cell carcinoma. Indian Journal of Dermatology, Venereology and Leprology, 81(2), 170–173. https://doi.org/10.4103/0378-6323.152286

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