The effects of taurine were modulated by the [Ca2+](i) or/and [Ca2+](o) levels, consistent with recent reports (10,28,31). Taurine may directly and indirectly regulate the [Ca2+](i) level by modulating Ca2+ channels (dependent on [Ca2+](i)/[Ca2+](o)) and Na+ channel (via Na+- Ca2+ exchange). Thus, taurine antagonizes Ca2+ ([Ca2+](o) or [Ca2+](i))-induced cardiac functions. The data for the effects of taurine on the ionic currents and action potentials (automaticity) are summarized in Tables 1 and 2. These results indicate that taurine exerts potent cardioprotective actions under the conditions induced by low Ca2+ level as well as by calcium overload. In conclusion, the effects of taurine are complex, there being a number of actions on cardiac muscle which may show the possible therapeutic use of this sulfur amino acid.
CITATION STYLE
Satoh, H. (1994). Cardioprotective actions of taurine against intracellular and extracellular calcium-induced effects. In Advances in Experimental Medicine and Biology (Vol. 359, pp. 181–196). Springer New York LLC. https://doi.org/10.1007/978-1-4899-1471-2_19
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