One goal of molecular imaging is to establish a widely applicable technique for specific detection of tumors with minimal background originated from non-target tissues. In this study, a smart activatable strategy for specific tumor imaging is proposed in which pH-activatable targeted probes specifically detect tumors after binding to the target cell surface proteins, internalization, and eventual acidic pH activation within the acidic organelles. We successfully visualized submillimeter-sized tumors using this strategy in two different tumor mouse models. Since the design of pH-activatable targeted probes can be applied to any target molecules on the cell surface that are to be internalized after ligand binding, this imaging strategy can afford a general and powerful method to diagnose and monitor the target tumors. © 2009 Humana Press.
CITATION STYLE
Asanuma, D., Kobayashi, H., Nagano, T., & Urano, Y. (2009). Fluorescence imaging of tumors with smart ph-activatable targeted probes. Methods in Molecular Biology, 574, 47–62. https://doi.org/10.1007/978-1-60327-321-3_5
Mendeley helps you to discover research relevant for your work.