Complement Factor H has recently come to the fore with variant forms implicated in a range of serious disease states. This review aims to bring together recent data concerning the structure and biological activity of this molecule to highlight the way in which a molecular understanding of function may open novel therapeutic possibilities. In particular we examine the evidence for and against the hypothesis that sequence variations in factor H may predispose to disease if they perturb its ability to recognise and respond appropriately to polyanionic carbohydrates on host surfaces that require protection from complement-mediated damage. © 2009 Springer-Verlag New York.
CITATION STYLE
Barlow, P. N., Hageman, G. S., & Lea, S. M. (2008). Complement factor H: Using atomic resolution structure to illuminate disease mechanisms. Advances in Experimental Medicine and Biology. Springer New York. https://doi.org/10.1007/978-0-387-78952-1_10
Mendeley helps you to discover research relevant for your work.