Innovative immunosensors for early stage cancer diagnosis and therapy monitoring

Abstract

This paper addresses the development of a diagnosis device based on optical and electrochemical principles for the detecting the levels of multiple mucin (MUC) type biomarkers. Combining surface plasmon resonance (SPR) and electrochemical techniques the selectivity can lead to improved sensitivity and reliability of the obtained transducer. The structures appropriate for an easy operated device, not requiring highly skilled operating personnel or expensive instrumentation, while offering fast, selective and accurate analytical response are investigated. A diagnosis device based on such combined immunosensor can greatly improve the chances of early diagnosis of ovarian cancer.