Thorotrast‐associated cholangiocarcinoma. An epidemiologic and clinicopathologic study

Abstract

Six cases of Thorotrast‐associated cholangiocarcinoma (TACC) are studied and compared with eight previously reported cases as well as with cases of non‐TACC. TACC shares some epidemiologic features both with non‐TACC as well as Thorotrast‐associated angiosarcoma (TAAS) but appears to occur in younger patients than non‐TACC. There is an apparent increased prevalence of both benign and malignant thyroid disease in the current group of patients with TACC; previous epidemiologic studies have not identified this phenomenon. Thorotrast‐associated hepatic fibrosis was present in all 14 TACC cases; otherwise, both non‐TACC and TACC are clinically and morphologically similar. Bile duct dysplasia and/or transition to adenocarcinoma, which occurred in all the AFIP cases, are seldom described in case reports of either TACC or non‐TACC; in the current study they served to validate the intrahepatic origin of the tumors. Copyright © 1982 American Cancer Society