Synthesis of new tetrazolyldienylphenothiazines as potential multidrug resistance inhibitory compounds

Abstract

Ring opening of tetrazolopyridinium salts with phenothiazines yielded stable cis-trans tetrazolyldienamines. One of the new derivatives proved to inhibit significantly the multidrug resistant efflux pump mechanism and, thus, these new phenothiazine derivatives are regarded as promising candidates for further drug research in the MDR area.