The different cytoskeleton systems and their connecting molecular motors move vesicles and intracellular organelles to shape cells. Polarized cells with specialized functions display an exquisite spatio-temporal regulation of both cytoskeletal and organelle arrangements that support their specific tasks. In particular, T cells rapidly change their shape and cellular function through the establishment of cell surface and intracellular polarity in response to a variety of cues. This review focuses on the contribution of the microtubule-based dynein/dynactin motor complex, the tubulin and actin cytoskeletons, and different organelles to the formation of the antigen-driven immune synapse.
CITATION STYLE
Martín-Cófreces, N. B., & Sánchez-Madrid, F. (2018, May 30). Sailing to and docking at the immune synapse: Role of tubulin dynamics and molecular motors. Frontiers in Immunology. Frontiers Media S.A. https://doi.org/10.3389/fimmu.2018.01174
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