Guanine quadruplexes (G4) are unusual four-stranded nucleic acid structures formed by G-rich DNA/RNA. Beyond their likely biological relevance, the self-assembly, stability, and rigidity of these structures are also interesting for nanotechnology and biotechnology applications. Therefore, efforts are carried out to understand the rules that govern stability and folding of G-quadruplexes. We focus this chapter on tetramolecular conformations which are simple tractable models.We report here the experimental parameters, molecules, and modifications that affect thermal stability and/or association kinetics of these structures. Some chemical modifications which facilitate tetramolecular quadruplex formation and can be useful for nano- or biotechnology are also described. Keywords
CITATION STYLE
Tran, P. L. T., De Cian, A., Gros, J., Moriyama, R., & Mergny, J.-L. (2012). Tetramolecular Quadruplex Stability and Assembly (pp. 243–273). https://doi.org/10.1007/128_2012_334
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