α-Arylation of Amides from α-Halo Amides Using Metal-Catalyzed Cross-Coupling Reactions

Abstract

Metal-catalyzed α-arylation of amides from α-halo amides with organometallic reagents is reviewed. The article includes Suzuki-Miyaura, Kumada-Corriu, Negishi, and Hiyama cross-coupling reactions. 1 Introduction 2 Suzuki-Miyaura Cross-Coupling 2.1 Palladium Catalysis 2.2 Nickel Catalysis 3 Kumada-Corriu Cross-Coupling 3.1 Nickel Catalysis 3.2 Iron Catalysis 3.3 Cobalt Catalysis 4 Negishi Cross-Coupling 5 Hiyama Cross-Coupling 6 Conclusion.