Evaluation of choroidal and retinal thickness measurements in adult hemodialysis patients using spectral-domain optical coherence tomography

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Abstract

Purpose: To assess the effect of hemodialysis on retinal and choroidal thicknesses using spectral-domain optical coherence tomography (SD-OCT). Methods: In this prospective interventional study, 25 hemodialysis patients (17 male, 8 female) were enrolled. All participants underwent high-speed, high-resolution SD-OCT (λ=840 mm; 26.000 A-scans/s; 5 μm resolution) before and after hemodialysis. Choroidal thickness was measured perpendicularly from the outer edge of the retinal pigment epithelium to the choroid-sclera boundary at the fovea and at five additional points: 500 μm and 1000 μm nasal to the fovea and 500 μm, 1000 μm, and 1500 μm temporal to the fovea. Two masked physicians performed the measurements. Choroidal and retinal thicknesses before and after hemodialysis were compared. Results: The median choroidal thicknesses before and after hemodialysis were 182 μm (range, 103-374 μm) and 161 μm (range, 90-353 μm), respectively (P < 0.001). The median retinal thicknesses were 246 μm (range, 179-296 μm) before and 248 μm (range, 141-299 μm) after hemodialysis (P > 0.05). Systolic arterial pressure, diastolic arterial pressure, mean arterial pressure, heart rate, and ocular perfusion pressure significantly decreased after hemodialysis (P < 0.001). Intraocular pressure did not vary significantly (P=0.540). Conclusion: Hemodialysis seems to cause a significant decrease in choroidal thickness, whereas it has no effect on retinal thickness. This significant decrease in choroidal thickness might be due to the extensive fluid absorption in hemodialysis, which could result in decreased ocular blood flow.

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Kal, A., Kal, O., Eroglu, F. C., Oner, O., Kucukerdonmez, C., & Yilmaz, G. (2016). Evaluation of choroidal and retinal thickness measurements in adult hemodialysis patients using spectral-domain optical coherence tomography. Arquivos Brasileiros de Oftalmologia, 79(4), 229–232. https://doi.org/10.5935/0004-2749.20160066

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