Male C57BL/6J, BALB/c, and DBA/2J mice showed differences in their abilities to perform two cognitive tests. C57BL/6J mice had good learning ability and memory trace retention (at 10 days) in a simplified Morris maze, while BALB/c mice had low levels of memory trace retention and DBA/2J mice had low learning ability in this test. I.p. administration of the nootropic agent Noopept (GVS-111, N-phenylacetyl-L-prolylglycine ethyl ester) at a dose of 0.5 mg/kg 15 min before the start of the test induced significant improvements in long-term memory in this test in BALB/c mice but no further improvement in C57BL/6J mice, and had no effect in DBA/2J mice. On testing the ability to extrapolate the direction of movement of a stimulus, administration of Noopept increased the proportion of correct responses in C57BL/6J and BALB/c mice, but had no effect in DBA/2J mice. © 2009 Springer Science+Business Media, Inc.
CITATION STYLE
Bel’nik, A. P., Ostrovskaya, R. U., & Poletaeva, I. I. (2009). Genotype-dependent characteristics of behavior in mice in cognitive tests. The effects of Noopept. Neuroscience and Behavioral Physiology, 39(1), 81–86. https://doi.org/10.1007/s11055-008-9095-1
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