Testosterone and sexual function

Abstract

Testosterone is the most defining of male hormones. Having low testosterone affects many aspects of male sexuality; however, the effects of low testosterone are variable. Data regarding treatment of low testosterone and its effects on sexual dysfunction are highly variable in quality and, in many areas, show conflicting results. In this review, we will review the hypothalamic-pituitary-gonadal axis as well as discuss animal and human data regarding the link between testosterone and erectile function. Furthermore, we discuss testosterone replacement and its effects on treatments for erectile dysfunction as well as present the limited data available regarding the possible association of Peyronie's disease and low testosterone. Finally, we discuss the effects of testosterone on libido and orgasmic function.