Randomized double-blind study of remifentanil and dexmedetomidine for flexible bronchoscopy

Abstract

Background. The safety profiles and efficacies of remifentanil and dexmedetomidine (a sedativeanalgesic without respiratory depression) for sedation during flexible bronchoscopy were investigated. Methods. Seventy-two patients undergoing elective flexible bronchoscopy were randomly assigned to a propofolremifentanil group (Group PR, n36) or a propofoldexmedetomidine group (Group PD, n36). The primary outcome was the incidence of oxygen desaturation. Haemodynamic variables, adverse events, need of oral cavity suction, cough scores, satisfaction scores of patients and bronchoscopists, levels of sedation, and recovery times were also compared. Results. The incidence of oxygen desaturation was significantly lower in the PD group than in the PR group (P0.01). There were no significant differences between groups in terms of level of sedation, oxygen saturation, mean arterial pressure, heart rate over time, cough scores, or patient satisfaction scores (P>0.05). However, cough scores and bronchoscopist satisfaction scores (P<0.01) were lower in the PD group. In addition, topical anaesthesia (P<0.01) was required more frequently and recovery time (P0.00) was significantly longer in the PD group. However, oral suction (P0.03) was required less frequently in the PD group. Conclusions. Dexmedetomidine was associated with fewer incidents of oxygen desaturation and a reduced need for oral cavity suction than remifentanil during flexible bronchoscopy. However, dexmedetomidine was associated with a longer recovery time and poorer bronchoscopist satisfaction score. © The Author [2011].