Animal Cell Technology: Challenges for the 21st Century

Abstract

Preface I. Asian Biotechnology in Future The role of Hong Kong SAR in the development of biotechnology industry in China A. Y. Chang II.Cell Culture and Engineering Increase in intracellular calcium influx enhances monoclonal antibody productivity S.-H. Park, J.-S. Park, M.-H. Nam Energy metabolism and antibody production based on flux analysis in hybridoma T. Omasa, T. Iemara, K, Furuichi, Y. Katakura, M. Kishimoto, K. Suga Transient transfection induces early cytosolic calcium signaling in CHO- K1 cells A. K. Preuss, H. M. Pick, F. Wurm, H. Vogel An on-line feeding strategy for fed-batch and dialysis cultures of hybridoma cells J. O. Schwabe, R. Pörtner, H. Märkl Effects of serum and other medium components on suspension culture of CHO cells producing tissue plasminogen activator M. Takagi, H. C. Hia, J. H. Jang, T. Yoshida Effects of osmotic pressure on metabolism of CHO cells producing tissue plasminogen activator in adhesion culture compared with that in suspension culture Cultivation of CHO cells on novel microcarriers M.Takagi,H.Hayashi,T.Yoshida A.Y. Hu, Z. Zhang, M. AI-Rubeai Bleeding strategy for the long-term perfusion culture of hybridoma J. W. Yun, S. Y. Lee, B. W. Choi, H. K Oh, J. S. Lee, B. H. Chun,W. G. Bang, T. H. Byun, S. Y.Park Metabolic flux distributions in hybridoma cells at ddifferent metabolic states P-C. Fu,A. Europa,A.Gambhir,W-S. Hu On-line detection of metabolic demand and changes to it: heat flux in continuous cultures of animal cells Y. H. Guan, K. B. Kemp Growth stimulation of CHO cells by phospholipids in serum-free culture K. Sakai, T. Matsunaga, H. Yamaji, H. Fukuda 57 63 A kinetic model of macromolecular monoclonal in hatch and fcii-hutch cultures of hybridoma cells producing monoclonal antibody J. D. Jang, J. P. Barford Enhancement of antibody productivity in the near-zero specific growth rate during glucose and glutamine-limited fed-batch culture of hybridoma cells J. D. Jang, J. P. Barford Long-term culture of CHO cells on porous microcarriers in a stirred tank equipped with a modified cell retention system X. Hu, C. Xiao, Z Huang, Z. Guo receptor from HEK 293 cells using perfusion through a packed bed bioreactor Continuous production and recovery of recombinant Ca++ J. B.Kaufman,G.Wang,W. Zhang,M.A.ValleJ.Shiloach 111. Production of Biologicals Characterization of recombinant bovine lactoperoxidase produced by CHO cells Expression of a soluble aß heterodimeric T cell receptor in animal cells M.Amano,M.Totsuka,K. Fujine,S.Yamada,S.Kaminogawa Posttranslational modifications of recombinant von Willebrand factor: Limitations and experimental improvement at high yield expression B. Plaimauer, U. Schlokat, M. Himmelspach, P. L. Turecek, H. P. Schwarz, F. G. Falkner, F. Dorner Incubation with heparin as an improved harvest method for high titre Disabled Infectious Single Cycle (DISC) HSV-2 from microcarrier cultures P. A. Wright, T. A. Zecchini, R. J. Smith, R. S. O’Keefe, N. K. Slater Passaging of microcarrier cultures as an alternative method for the seeding of large scale bioreactors for the production of high titre Disabled Infectious Single Cycle HSV-2 vaccine (DISC HSV) T.A.Zecchini, P.A.Wright, R. J. Smith The hybrid system using both promoter activation and gene amplification for establishment of exogenous protein hyper-producing cell lines K. Teruya, X.-Y. Dong, Y. Daimon, Y. Katakura, Y.-P. Zhang, P. Seto,T.Miura,H.Ohashi, S. Shirahata 123 System for large scale protein expression in Bombyx mori T. Arakawa, M. Miyazawa, S. Tomita, N. Yonemura, S. Hayasaka 129 IV. Functional Cell Lines Protein-free culture of ras-amplified recombinant BHK-21 cells Y. Inoue, S. Kawamoto, M. Shoji, S. Hashizume, K. Teruya, Y. Katakura, S. Shirahata Effect of sugar composition on the heterogeneity of antibody in hybridoma cultivation T.Omasa, Y.Kitamoto. J.Tanaka, Y.Katakura,M.Kishimoto.K. Suga Modulation of antigen binding of human antibody via a glycosylation by hybridoma culture with various carbon sources J-Y.Kim,Y.Katakura,K.Teruya,S.Shirahata VI. Immunologicals, Monoclonal Antibodies andVaccines Manipulation of cytokine production from CD8+ acid-substitutedanalogsofapeptide antigen T cells by means of amino M. Totsuka, M. Kohyama, M. Kakchi, S. Hachimura, T. Hisatsune, S.Kaminogawa A novel effect of nivalenol (NIV) on the immune response NIV, a trichothecene mycotoxin selectively inhibits antigen-specific Th2 responses C-Y. Choi, H. Nakajima-Adachi, S. Kaminogawa, S. Kumagai, Y. Sugila-Konishi Human-human hybridomas producing monoclonal antibodies reactive to house dust mites antigen H. Kawahara, M. Maeda-Yamamoto, M. Suzuki, K. Osada, K. Tsuji 161 Establishment of human-mouse hybridomas secreting antibodies to rice- allergens H. Shinmoto,K.Nakahara, R. Ichikawa,M.Kobori,T.Tsushida VII. Transplantation and Artificial Organs Cell culture engineering using intelligent biomaterials Y.Ito Spatial development of mouse bone marrow cells cultivated in porous carriers Y.Tomimori,M.Takagi,T.Sasaki,T.Yoshida Tumor promoting mechanism of biomaterials: No involvement of mutation in cx43 gene in the tumorigenesis induced by polyurethanes in vitro T.Tsuchiya,M.A.Sayed,A.Nakamura Xenotransplantation of cultured newborn pig thyroid tissue for the treatment of post-radioiodine hypothyroidism in rats I. P. Pasteur, M. D. Tronko, I. I. Drozdovich, L. M. Voitenko, S. F. Donich VIII. Gene Therapy Improved production of retroviral vectors under serum-free conditions for the application of gene therapy P. A. Gerin, P. F. Searle, M. AI-Rubeai Large scale production of rh-albumin expressed in the milk of transgenic cattle - An economic and technical challenge W.Eichner,K.Scmmermeyer Transgenic rabbits: A novel model for the study of atherosclerosis J. Fan, M. Araki, L. Wu, M. Challah, H. Shimoyamada, R. M. Lawn, H. Kakuta, H. Shikama, T. Watanabe In vivo gene transfer to chicken via blastodermal cells of early developmental embryos S. Inada,M.Hattori,N. Fujihara X. Safety and Regulations Overview of the international endeavor toward harmonization of technical requirements for the control of new medicines from biotechnology T. Hayakawa Reducingrisksof animal origincontaminants in cell culture D. W. Jayme, S. R. Smith, M. Z. Plavsic Large scale production of rh-albumin expressed in the milk of transgenic cattle - An economic and technical challenge W.Eichner,K.Scmmermeyer Transgenic rabbits: A novel model for the study of atherosclerosis J. Fan, M. Araki, L. Wu, M. Challah, H. Shimoyamada, R. M. Lawn, H. Kakuta, H. Shikama, T. Watanabe In vivo gene transfer to chicken via blastodermal cells of early developmental embryos S. Inada,M.Hattori,N. Fujihara X. Safety and Regulations Overview of the international endeavor toward harmonization of technical requirements for the control of new medicines from biotechnology T. Hayakawa Reducingrisksof animal origincontaminants in cell culture D. W. Jayme, S. R. Smith, M. Z. Plavsic Antitumor protein (AP) from a mushroom induced apoptosis to transformed human keratinocyte by controlling the status of pRB, c-myc, cyclin E-CDK2, and p21WAF1 in the GI/S transition Y.Kawamura,M.Manabe,K.Kitta Transformation of NIH/3T3 and C3H/10T1/2 cells by citrinin and ochratoxin A Senescence induction in cancer cells Y. Katakura, T. Miura. N. Uehara, E. Nakata, S. Shirahata Growth characteristics of NIH3T3 cells expressing bFGF and/or IGF-I and/or IGF-II D. Li, S. Hettle, J. McLean, C. MacDonald Targeted disruption of a mitochondrial transcription factor A in the chicken DT40 cell lines Y. Matsushima, K. Malsumura, S. Isaii, Y. Kitagawa Expression and characterization of mouse epidermal transglutaminase in baculovirus-infected insect cells K.Hitomi,K. Ikura,M.Maki Effect of tea polyphenols on degranulation in human mature basophils differentiated with IL-4 H. Tachibana, Y. Sunada, T. Hara, K. Yamada Counteraction of the active form of vitamins A and D on up-regulation of adipocyte differentiation with PPARγ ligand, A thiazolidinedione, in 3T3- L1 cells (Japan), R. S. (1998). animal cell technology: challenges for the 21st century. Telomere shortening in cancer cells by electrolyzed-reduced water S. Shirahata. E. Murakami. K. Kusumoto, M. Yamashita, M. Oda. KTeruya, S.Kabayama,K.Orsuho,S.Morisawa.H. Hayashi.Y. Katakura Acetic acid suppresses the increase of glycosidase activity during culture of Caco-2 intestinal epithelial cells N. Ogawa, H. Satsu, H. Watanabe, M. Fukaya, Y. Tsukamoto. Y. Miyamoto,M.Shimizu Effects of digested skim milk on the proliferation activity of human acute myeloid leukemia (HL-60) cells M.K. Roy,Y.Watanabe,Y.Tamai Differentiation-inducing activity of human leukemia cell lines by extracts of wild plants, seaweed and mushrooms in Akita K. Hata, K. Ishikawa, K. Hori Anti-tumorigenic protein from Aralia elata The induction of apoptosis in transformed cells M.Tomatsu,K. Ishikawa,N.Shibamoto Suppression of UV damage-induced apoptosis of human melanoma cells by a fermented milk, Kefir Recognition system for dietary fatty acids in the rat small intestinal cells and taste buds T. Fushiki, T. Fukuwatari, T. Kawada, M. Tsuruta, T. Hiraoka, T. Iwanaga, E. Sugimoto Effect of rose bengal on immunoglobulin production by mouse B lymphoma, WEHI-279 cells Y. Kuramoto, Y. Miyanki, S.hue, A. Fujise, Y. Yamaguchi, H.Kawahara,H.Tachibana,M.Sugano.K.Yamada Class-specific regulation of immunoglobulin production by rose bengal in human B cell lines and peripheral blood lymphocytes Y. Miyazaki, Y. Kuramoto, H. Haruta, H. Tachibana, M. Sugano, K. Yamada Inhibitory action of carotenoids in crab shell on the invasion of hepatoma cells eo-cultured with mesothelial cells The neurite-initiating effect of microbial extracellular glycolipids Induction of basophilic and eosinophilic differentiation in the human leukemia cell line KU812 Mannosylerythritol lipid induced apoptosis and differentiation of melanoma B16 cells X. Zhao, T. Sudo. Y. Wakamatsu, M. Shibahara, T Nakahara, T. Murata, K. Yokoyama