Effect of cell bound hyaluronic acid on infectivity of Newcastle disease virus for human synovial cells in vitro

Abstract

Cell strains derived from human synovium were exposed to infection by the paramyxovirus of Newcastle disease. No significant difference was detected in the susceptibility of rheumatoid and non rheumatoid lines. Prior treatment of the cells with hyaluronidase enhanced the susceptibility of both cell types to virus infection. It is concluded that cell bound hyaluronic acid interferes with the adsorption of virus to synovial cells.