A method for the separation of the homologous series of benzalkonium chloride (BAK), benzyl chloride, and possible byproducts is presented. Under recommended conditions, 2 mobile phases (isocratic and gradient elutions, depending on the impurities present) are proposed. A study of the kinetics of the removal of benzyl chloride under different conditions (catalyst, excess of amine, different solvents) allows the synthesis of BAK without residual benzyl chloride.
CITATION STYLE
Prieto-Blanco, M. C., López-Mahía, P., & Prada-Rodríguez, D. (1999). Analysis of residual products in benzalkonium chloride by high-performance liquid chromatography. Journal of Chromatographic Science, 37(8), 295–299. https://doi.org/10.1093/chromsci/37.8.295
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