Analysis of residual products in benzalkonium chloride by high-performance liquid chromatography

Abstract

A method for the separation of the homologous series of benzalkonium chloride (BAK), benzyl chloride, and possible byproducts is presented. Under recommended conditions, 2 mobile phases (isocratic and gradient elutions, depending on the impurities present) are proposed. A study of the kinetics of the removal of benzyl chloride under different conditions (catalyst, excess of amine, different solvents) allows the synthesis of BAK without residual benzyl chloride.