Alternative Regimens of Neuraminidase Inhibitors for Therapy of Hospitalized Adults with Influenza: A Systematic Review of Randomized Controlled Trials

5Citations
Citations of this article
28Readers
Mendeley users who have this article in their library.

This article is free to access.

Abstract

Introduction: Influenza in hospitalized intensive care unit (ICU) patients with respiratory failure is associated with 25% mortality, despite timely oseltamivir treatment. A systematic review of randomized controlled trials (RCTs) was conducted to evaluate the efficacy and safety of alternative neuraminidase inhibitor (NAI) regimens compared to standard of care in patients hospitalized for H1N1, H3N2, or B influenza. Methods: The Cochrane collaboration searching methods were followed in Cochrane Library, PubMed, and Web of Science databases (2009–2019). Eligibility criteria were RCTs comparing different regimens of NAIs in hospitalized patients (at least 1 year old) for clinically diagnosed influenza (H1N1, H3N2, or B). Pre-defined endpoints were time to clinical resolution (TTCR), overall mortality, hospital discharge, viral clearance, drug-related adverse events (AEs), and serious adverse events. Results: Seven trials (1579 patients) were included. Two trials compared two regimens of oral oseltamivir therapy, and one trial compared two regimens of intravenous zanamivir therapy vs oral oseltamivir therapy. Four trials focused on intravenous peramivir therapy: two trials compared two different regimens and two trials compared two different regimens vs oral oseltamivir therapy. Overall, the different regimens were well tolerated, with no significant differences in AEs; nonetheless non-significant differences were reported among different regimens regarding TTCR, mortality, and viral clearance. Conclusion: Higher compared to standard doses of NAIs or systemic peramivir therapy compared to oral oseltamivir therapy did not demonstrate benefit.

References Powered by Scopus

Cochrane handbook for systematic reviews of interventions

36728Citations
N/AReaders
Get full text

The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration

8814Citations
N/AReaders
Get full text

Estimating the mean and variance from the median, range, and the size of a sample

7006Citations
N/AReaders
Get full text

Cited by Powered by Scopus

Comparative review of respiratory diseases caused by coronaviruses and influenza A viruses during epidemic season

69Citations
N/AReaders
Get full text

Neuraminidase inhibitors and single dose baloxavir are effective and safe in uncomplicated influenza: a meta-analysis of randomized controlled trials

14Citations
N/AReaders
Get full text

Neuraminidase inhibitors are effective and safe in reducing influenza complications: meta-analysis of randomized controlled trials.

11Citations
N/AReaders
Get full text

Register to see more suggestions

Mendeley helps you to discover research relevant for your work.

Already have an account?

Cite

CITATION STYLE

APA

Tejada, S., Campogiani, L., Solé-Lleonart, C., & Rello, J. (2020, June 1). Alternative Regimens of Neuraminidase Inhibitors for Therapy of Hospitalized Adults with Influenza: A Systematic Review of Randomized Controlled Trials. Advances in Therapy. Adis. https://doi.org/10.1007/s12325-020-01347-5

Readers' Seniority

Tooltip

PhD / Post grad / Masters / Doc 6

60%

Researcher 2

20%

Professor / Associate Prof. 1

10%

Lecturer / Post doc 1

10%

Readers' Discipline

Tooltip

Medicine and Dentistry 9

69%

Engineering 2

15%

Nursing and Health Professions 1

8%

Social Sciences 1

8%

Save time finding and organizing research with Mendeley

Sign up for free