Efferocytosis is the process of recognizing and removing dead and dying cells, performed by a variety of phagocytic cells including macrophages. It has recently been shown that liver X receptor (LXR) signaling in macrophages regulates the expression of important efferocytosis receptors, bridging and signaling molecules. Here we describe a sensitive yet robust efferocytosis assay, optimized to measure bone marrow-derived macrophage (BMDM) apoptotic cell engulfment capability. This assay can be applied to genetically or pharmacologically altered BMDMs.
CITATION STYLE
Gage, M. C. (2019). Measuring apoptotic cell engulfment (efferocytosis) efficiency. In Methods in Molecular Biology (Vol. 1951, pp. 143–152). Humana Press Inc. https://doi.org/10.1007/978-1-4939-9130-3_11
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