Abstract
The mitochondrial connection in cancer has long been suspected, but the first unequivocal genetic link was established only when hereditary paraganglioma-associated mutations were found in genes coding for the subunits of mitochondrial complex II. In this chapter we provide an overview of current knowledge concerning the involvement of complex II in cancer, and discuss molecular mechanisms that may contribute to complex II-mediated tumourigenesis.
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Kluckova, K., Neuzil, J., & Rohlena, J. (2014). Mitochondrial complex II in cancer. In Mitochondria: The Anti-Cancer Target for the Third Millennium (pp. 81–104). Springer Netherlands. https://doi.org/10.1007/978-94-017-8984-4_4
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