Overnight closed-loop insulin delivery in patients with type 1 diabetes

Abstract

The artificial pancreas or automated closed-loop insulin delivery system is an emerging technology to treat type 1 diabetes aiming to safely achieve and maintain near normal glucose levels. The main components are a continuous glucose monitor, a subcutaneous insulin infusion pump and a control algorithm, which computes, in real-time, the amount of insulin to be delivered by the pump. The research focus at the University of Cambridge is to develop a closed-loop system prototype for overnight use employing off-the-shelf devices and using model predictive control algorithm. We have tested the closedloop system overnight in both younger and older patient with T1D, demonstrating improvement in glucose control and reduction in nocturnal hypoglycemia. © 2011 Springer-Verlag Berlin Heidelberg.