In this study, the plastic change in the auditory cortex induced by fear conditioning with pairing of sound (Conditioned Stimulus, CS) and electric foot-shock (Unconditioned Stimulus, US) was investigated by using of an optical recording. To investigate the effect of associated learning, optical signals in the auditory cortex to CS (12 kHz pure tone) and non-CS (8 kHz and 16 kHz pure tone) were recorded before and after the conditioning. As a result, the response area only to CS increased after the conditioning. On the other hand, to investigate whether auditory information could be retrieved by electric foot-shock after associated learning or not, auditory response to foot-shock alone was also investigated. As a result, the optical response in the auditory cortex to electric foot-shock alone could not be observed before the conditioning but clearly appeared after the conditioning. © 2009 Springer Berlin Heidelberg.
CITATION STYLE
Ide, Y., Lauwereyns, J., & Tsukada, M. (2009). Optical imaging of plastic changes induced by fear conditioning in the auditory cortex of guinea pig. In Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics) (Vol. 5506 LNCS, pp. 416–422). https://doi.org/10.1007/978-3-642-02490-0_51
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