Ring-opening of epoxides with amines for synthesis of β-amino alcohols in a continuous-flow biocatalysis system

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Abstract

An efficient method for the preparation of β-amino alcohols catalyzed by lipase TL IM from Thermomyces lanuginosus in a continuous-flow reactor was developed. The eco-friendly biocatalyst combined with continuous-flow reaction technology displayed high efficiency in the synthesis of β-amino alcohols. The benign reaction conditions (35 °C) and short residence time (20 min), together with the use of low cost and readily available starting materials, make this synthetic approach a promising alternative to current β-amino alcohol synthesis.

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Du, L. H., Miao-Xue, Yang, M. J., Yue-Pan, Zheng, L. Y., Ou, Z. M., & Luo, X. P. (2020). Ring-opening of epoxides with amines for synthesis of β-amino alcohols in a continuous-flow biocatalysis system. Catalysts, 10(12), 1–13. https://doi.org/10.3390/catal10121419

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