Absolute Stereostructures of Hovenidulciosides A1 AND A2, Bioactive Novel Triterpene Glycosides From Hoveniae Semen Seu Fructus, The Seeds and Fruit of Hovenia Dulcis Thunb

Abstract

Two bioactive novel triterpene glycosides named hovenidulciosides A1 and A2 have been isolated from a Chinese natural medicine, Hoveniae Semen Seu Fructus, the seeds and fruit of Hovenia dulcis Thunb. (Rhamnaceae). The absolute stereostructures of hovenidulciosides A1 and A2 with a migrated 16,17-seco-dammarane skeleton have been determined on the basis of chemical and physicochemical evidence which included the X-ray crystallographic analysis of the p-bromobenzoate of their common aglycone, hovenidulcigenin A. Hovenidulciosides A1 and A2 exhibited inhibitory activity on the histamine release from rat mast cells induced by compound 48/80 or calcium ionophore A-23187. © 1995, The Pharmaceutical Society of Japan. All rights reserved.