Synthetic, spectroscopic and biocidal aspects of some boron complexes of azomethines derived from 1-(2-furanyl) ethanone

Abstract

Synthetic and spectroscopic aspects of boron complexes of some biologically potent azomethines having nitrogen-oxygen and nitrogen-sulphur donor systems have been carried out. The azomethines were prepared by the condensation of carbonyl compound, 1-(2-furanyl)ethanone with semicarbazide hydrochloride, thiosemicarbazide, and 2-mercaptoaniline. The resulting coloured solids are monomers and non-electrolytes. These have been characterized by elemental analysis, molecular weight determinations and spectral studies including IR, 1H NMR, 11B NMR and 13C NMR. Based on spectral data tri-coordinated boron in the starting materials and tetra-coordinated in the resulting complexes have been confirmed. The azomethines and their boron complexes have been screened for their antifungal and antibacterial properties. It is evident that though the azomethines alone were quite toxic but their activity increased after complexation.